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反应剂和产品的协同合效应促进了Sir2中的脱乙烯化循环

Zhen Bai1, Duy Phuoc Tran1, Akio Kitao1

  • 1School of Life Science and Technology, Institute of Science Tokyo, 2-12-2 Ookayama, Meguro, Tokyo 152-8550, Japan.

Journal of chemical information and modeling
|October 13, 2025
PubMed
概括

通过辅因子结合循环动态,Sir2脱乙酶活性由p53乙化调节. 乙化p53的结合打开了NAD+的口袋,通过tandemallostery增强了脱乙化.

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