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Updated: Jan 15, 2026

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis
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Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

Published on: January 7, 2017

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基准测试 化学 相对结合 自由能量 核酸结合多重体ATPases的计算

Apoorva Purohit1, Xiaolin Cheng1

  • 1Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and Translational Data Analytics Institute, The Ohio State University, Columbus, Ohio 43210, United States.

Journal of chemical theory and computation
|October 13, 2025
PubMed
概括

化学相对结合自由能量 (RBFE) 的计算准确地预测了大多数多重体ATPases中的核酸结合,其准确性取决于蛋白质的结构稳定性. 这项研究对复杂蛋白质系统的RBFE方法进行了基准测试.

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