与艾滋病毒老龄化:多病症和多药物的负担
Nazife Duygu Demirbas1, Husrev Diktas2, Ozlem Gul1
1Department of Infectious Diseases and Clinical Microbiology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Türkiye.
AIDS care
|October 13, 2025
概括
携带艾滋病毒的老年人 (PLWH) 面临更高的多种健康状况和多种药物治疗率. 这项研究强调了需要量身定制的护理策略来管理这些复杂的健康需求在老化PLWH.
科学领域:
- 老年医学 老年医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 艾滋病毒感染者 (PLWH) 的老年人群越来越多地被认为是多病症和多药症风险较高的人群.
- 这些情况在管理老年PLWH接受抗逆转录病毒疗法 (ART) 的医疗需求方面存在重大挑战.
研究的目的:
- 为了确定与艾滋病毒阴性对应物相比,老年PLWH中多发病率和多药性的流行率.
- 在这个人口群体中识别与多病症和多药性相关的风险因素.
主要方法:
- 采用横截面研究设计,将50岁及以上的PLWH与没有艾滋病毒的年龄和性别匹配的对照进行比较.
- 后勤回归分析被用来确定多药学的独立预测因素.
主要成果:
- 在PLWH (29%) 中,多发病率比对照组 (22%) 更为普遍,骨质疏松症和精神疾病的发病率明显更高.
- 多药性 (≥5种非ART药物) 在PLWH中也更频繁 (20.4%对11.8%).
- 多药学的独立预测因素包括艾滋病毒状况,年龄增长和缺乏正规教育. 药物相互作用很常见,特别是在那些使用多种药物的药物中.
结论:
- 较老的PLWH与HIV阴性个体相比,具有更大的多病症和多药性负担.
- 实施有针对性的干预措施,包括药物审查,药物相互作用监测和预防护理,对于改善老龄化人口的健康结果至关重要.
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