中性细胞-淋巴细胞比率与患有人类免疫缺陷病毒的儿童的眼睛表现之间的关系
1Department of Ophthalmology, University of North Sumatra, Medan, Indonesia.
概括
升高的中性粒细胞-淋巴细胞比率 (NLR) 与患有人类免疫缺陷病毒 (HIV) 的儿童的眼睛问题有关. 通过定期的眼部查及抗逆转录病毒疗法 (ARV) 的早期检测对于预防视力丧失至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 患有人类免疫缺陷病毒 (HIV) 的儿童面临视力威胁的眼部并发症的风险增加.
- 在发展中国家,艾滋病毒和相关并发症的患病率正在上升.
- 眼部表现可以显著损害儿童艾滋病毒患者的视力和生活质量.
研究的目的:
- 调查中性粒细胞-淋巴细胞比率 (NLR) 和艾滋病毒感染儿童眼部表现之间的关联.
- 为了确定潜在的炎症标志物,表明儿童艾滋病毒的眼睛疾病.
- 探索细胞巨乳病毒 (CMV) 感染在这些眼部并发症中的作用.
主要方法:
- 印度尼西亚梅丹75名艾滋病毒阳性儿童 (5-18岁) 的横截面研究.
- 综合眼科检查,包括视力敏度,裂纹灯生物显微镜和眼底镜.
- 中性粒细胞-淋巴细胞比率 (NLR) 分析和细胞巨乳病毒 (CMV) PCR测试.
主要成果:
- 较高的平均NLR (1.76) 与眼部表现有显著的相关性 (p=0.024).
- 细胞巨乳病毒 (CMV) PCR阳性与视力模糊 (OR=6.63),眼睛红 (OR=4.75),角膜痕 (OR=16.00) 和鼻化 (OR=16.00) 有显著的相关性.
- 常见的眼部投诉包括视力模糊和眼睛红/;前后段发现也被注意到.
结论:
- 升高的NLR与儿科艾滋病毒患者的眼部表现有关,特别是那些有CMV共感染的患者.
- 定期的眼科查对于在这个人群中早期发现眼病至关重要.
- 坚持抗逆转录病毒疗法 (ARV) 和迅速管理CMV对于维护视力至关重要.
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