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Updated: Jan 15, 2026

Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells
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Tyramide Signal Amplification for the Immunofluorescent Staining of ZBP1-Dependent Phosphorylation of RIPK3 and MLKL After HSV-1 Infection in Human Cells

Published on: October 20, 2022

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宿主细胞Z-RNA在病毒感染期间激活ZBP1

Chaoran Yin1, Aleksandr Fedorov2,3, Hongyan Guo4

  • 1Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.

Nature
|October 13, 2025
PubMed
概括

宿主细胞Z-RNAs,而不是病毒,在单纯疹病毒1和流感A病毒感染期间激活Z-形式核酸结合蛋白1 (ZBP1). 这种细胞死亡反应对抗病毒对宿主转录的破坏.

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