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Updated: Jan 15, 2026

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无意义基因变异对OATP1B1表达和输送活动的 in vitro 影响

Wilma Kiander1, Hatam Rashidpour2, Mikko Gynther3

  • 1Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Department of Clinical Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Individualized Drug Therapy Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Clinical Pharmacology, HUS Diagnostic Centre, Helsinki University Hospital, Helsinki, Finland.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
|October 13, 2025
PubMed
概括

研究SLCO1B1基因变异,这项研究揭示了大多数无意义的变异显著减少有机离子运输聚1B1 (OATP1B1) 功能和膜表达,可能会增加药物的血度.

关键词:
框架移位是指框架移位.这是无稽之谈.这是一个OATP1B1B1的OATP.药物遗传学 药物遗传学罗苏瓦斯塔丁是一种葡萄素.在SLCO1B1B1中,变种 变种 变种 变种

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