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孕期婴儿中的益生菌:婴儿类型双菌的临床影响:系统性审查和元分析
Mathias A Sjælland1, Marie T Philipsen2, Tine B Henriksen2
1Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
早期使用婴儿类型双菌 (ITB) 益生菌可以减少婴儿的湿疹和呼吸道感染. 需要更多的研究来证实这些好处,并确定婴儿肠道健康的最佳使用.
科学领域:
- 微生物学和免疫学
- 儿科健康 儿科健康
- 营养科学 营养科学
背景情况:
- 婴儿类型的双胞胎菌 (ITB) 益生菌,如B. longum亚种. 婴儿,越来越多地被认为具有塑造婴儿肠道微生物组和免疫系统的潜力.
- 尽管人们对ITB益生菌的兴趣日益增长,但仍然存在关于ITB益生菌在婴儿中的临床疗效,最佳菌株,剂量和持续时间的重大知识差距.
- 了解这些因素对于利用ITB益生菌来改善婴儿健康结果至关重要.
研究的目的:
- 系统地审查和评估ITB-益生菌在健康的婴儿的临床效应,在生命的第一年.
- 评估ITB益生菌对各种临床结果的影响,包括亚托皮性疾病,胃肠道健康,生长和感染率.
- 综合当前的证据,并确定ITB-益生菌适用于婴儿的未来研究领域.
主要方法:
- 在主要数据库中进行了全面的系统搜索:PubMed,Embase,CENTRAL和Scopus.
- 包括25项研究,并使用修订后的Cochrane RoB 2工具评估偏差风险.
- 在适用的情况下,对特定结果的数据进行了元分析.
主要成果:
- 早期ITB-益生菌的使用与疹的统计显著减少有关 (RR = 0.78).
- 观察到呼吸道感染的边界显著减少 (RR = 0.74).
- 对于抗生素使用,腹,喘支气管炎和食物过敏,观察到预防效果的趋势,但这些并没有达到统计学意义.
结论:
- ITB-益生菌显示出潜在的临床相关性,特别是在预防赤和呼吸道感染的婴儿.
- 目前的证据受到研究异质性和缺乏长期随访数据的限制.
- 高质量的,大规模的随机对照试验是必要的,以确认短期和长期的影响,并标准化ITB-益生菌在婴儿使用的结果措施.
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