基于协同非共价相互作用的多功能自凝血止血粉末,用于快速止血和感染伤口愈合
Xiaohui Li1, Minglun Cai1, Jiawei Gao1
1State Key Laboratory of Separation Membranes and Membrane Processes& Key Laboratory of Hollow Fiber Membrane Materials and Membrane Processes (MOE) & Tianjin Key Laboratory of Hollow Fiber Membrane Materials and Processes, School of Materials Science and Engineering, Tiangong University, Tianjin, 300387, China; Cangzhou Institute of Tiangong University, Cangzhou 061000, China.
Acta biomaterialia
|October 13, 2025
概括
一种新型的自凝血止血粉末 (P-pUMAA/QCS) 通过结合尿素功能化甲基酸和四分化奇托,可快速控制严重出血. 这种先进的材料表现出优越的粘附性和机械强度,可有效控制出血和伤口愈合.
科学领域:
- 生物材料科学 生物材料科学
- 化学工程是化学工程的重要组成部分.
- 医疗器械 医疗器械
背景情况:
- 严重的出血是一个关键的临床挑战,特别是来自于不可压缩的伤口或在不利的生理条件下.
- 目前的静血剂通常在粘附性,机械强度和稳定性方面表现出局限性,这阻碍了它们在苛刻情况下的有效性.
研究的目的:
- 开发一种合理设计的,自凝结的静血粉末 (P-pUMAA/QCS),解决现有的静血材料的局限性.
- 为了利用协同非共价相互作用来增强血静,粘附和机械性能.
主要方法:
- 分子设计包括尿素功能化甲酸 (UMAA) 用于键和四分化酸盐 (QCS) 用于静电相互作用.
- 在血液和酸性液体中进行现场自凝结评估,湿组织粘附测试,以及在动脉压下评估机械完整性.
- 在具有挑战性的出血模型和受感染伤口愈合研究中的体内评估.
主要成果:
- P-pUMAA/QCS表现出超快速的现场自我凝结 (在血液中<15秒,在酸性液体中<3秒).
- 实现了强大的湿组织粘附性 (高达76kPa) 和能够承受动脉压 (>140mmHg) 的机械完整性.
- 证明了良好的生物相容性,强大的抗菌活性,加速受感染的伤口愈合,以及快速的血液静止 in vivo.
结论:
- 协同非共价相互作用方法产生了一种高性能静血粉末,具有卓越的粘附性和机械性能.
- P-pUMAA/QCS为先进的出血控制和伤口管理提供了一个有前途的多功能平台.
- 这种分子设计策略为开发下一代静血剂提供了基础.
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