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Updated: Jan 15, 2026

Establishment of a Surgically-induced Model in Mice to Investigate the Protective Role of Progranulin in Osteoarthritis
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衰老会通过PGRN/EGFR/PI3K/AKT轴损害与Treg相关的骨质诱导过程

Yuwei Zhou1, Wenqian Chen1, Chengchaozi Wang1

  • 1School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.

International journal of biological macromolecules
|October 13, 2025
PubMed
概括

调节衰老的T细胞 (Tregs) 分泌的progranulin (PGRN) 减少,从而影响骨的形成. 补充PGRN可以恢复骨质生成潜力,为与年龄相关的骨修复提供治疗策略.

关键词:
细胞相互作用 细胞相互作用欧洲农业基金会 (EGFR) 是一个.骨质分化的骨质分化在PGRNN中使用.陈年的人是老年人.这是Tregs.

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