相关实验视频

Updated: Jan 15, 2026

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

瘤微环境和宏观环境:对整体瘤学的新视角

Qun Chen¹, Kuirong Jiang², Michael S Bronze¹

¹Department of Medicine, The University of Oklahoma Health Campus, Oklahoma City, OK, 73104, USA.

|October 13, 2025

概括

瘤微环境 (TME) 和瘤宏环境 (TMaE) 相互作用,影响癌症进展和治疗结果. 了解这种局部-系统交响对于开发先进的癌症疗法至关重要.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
免疫学免疫学免疫学

背景情况:

瘤微环境 (TME) 和瘤宏环境 (TMaE) 是癌症发病,进展和治疗耐药性的关键决定因素.
TME包括局部细胞,而TMaE集成了诸如新陈代谢,免疫力和炎症等系统信号.
目前的模型无法充分反映癌症局部和系统因素之间的复杂相互作用.

研究的目的:

审查TME和TMaE在塑造癌症生物学中的不同和重叠的角色.
突出系统因素影响局部瘤生态系统的机制.
强调需要综合模型来理解癌症的局部系统交叉通话.

主要方法:

对癌症生物学近期进展的文献综述,重点关注TME和TMaE相互作用.
分析系统生理因素如何影响瘤进展和治疗反应.
讨论目前概念化和建模TME-TMaE交叉通话的局限性.

主要成果:

无论是TME还是TMaE都是瘤发病,进展,休眠和转移的组成部分.
系统性因素 (衰老,代谢失衡,炎症,压力) 显著重塑TME并影响癌症的结果.
局部瘤和系统生理学的相互作用是复杂的,双向的.

结论:

对TME-TMaE相互作用的全面理解对于完善精确瘤学和预防策略至关重要.
未来的研究应该整合多omics,先进的成像和人性化的模型,以阐明局部-系统交叉通话.
针对本地和全身癌症生态系统,为组合疗法提供了一个有希望的途径.

关键词:

豁免权是一种豁免权.地方-系统交叉连接精确的处理精确的处理瘤的宏观环境瘤微环境是一个微环境.

更多相关视频

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

In Vitro Assay to Study Tumor-macrophage Interaction

In Vitro Assay to Study Tumor-macrophage Interaction

Published on: August 1, 2019

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Dimensions of Health and Illness

Dimensions of Health and Illness

The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.

Cancer Stem Cells and Tumor Maintenance

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...