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完全集成的微流体平台与磁传感相结合,可快速检测心血管疾病生物标志物

Bo Bao¹, Xinran Tian¹, Ridong Wang¹

¹State Key Laboratory of Precision Measurement Technology and Instruments, Tianjin University, Tianjin 300072, China.

Analytical chemistry

|October 13, 2025

概括

一个新的微流体磁传感平台能够快速,灵敏地检测心型脂肪酸结合蛋白 (H-FABP),用于早期急性心肌梗塞诊断. 这种自动化系统为快速的护理点查提供了潜力.

科学领域:

生物标志物检测检测生物标志物检测
心血管诊断心血管诊断
微流体系统微流体系统

背景情况:

诊断急性心肌梗塞 (AMI) 需要快速,敏感的生物标志物.
检测心型脂肪酸结合蛋白 (H-FABP) 等生物标志物的传统方法通常是复杂和耗时的.
需要自动化,高效的诊断工具来早期检测AMI.

研究的目的:

开发一个集成的微流体平台,具有磁传感,用于快速检测H-FABP.
提高生物标志物检测的灵敏度和效率,以早期诊断AMI.
为了创建一个适合于点的护理应用和大规模查的系统.

主要方法:

设计了一个多功能微流体芯片,具有主动-被动混合,微线圈和磁传感区域.
一个自旋交换无放松 (SERF) 原子磁计被用于高分辨率的磁场映射.
该系统集成了芯片上预处理,用于快速生物标志物分析.

主要成果:

开发的平台实现了具有pT范围灵敏度的高分辨率磁场映射.
对H-FABP的检测极限被确定为1.57 pg/mL.
整个检测过程,包括样本准备,在25分钟内完成.

结论:

集成的微流体磁传感系统为H-FABP检测提供了灵敏和快速的方法.
该平台的紧设计,高灵敏度和快速处理能力非常适合于医疗点诊断.
这项技术显示出早期疾病查和改善心血管诊断中的临床结果的巨大潜力.

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