生物活性胰岛素类生长因子 (IGF-I) 度在接受生长激素治疗的儿童中
Lea Vilmann1,2, Jakob Albrethsen1,2, Jørgen Holm Petersen1,2,3
1Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
监测生物活性胰岛素类生长因子 (IGF) -I水平可以帮助优化儿童生长激素 (GH) 治疗. 生物活性IGF-I在大多数GH治疗患者中保持在正常范围内,这表明有可能进行个性化治疗调整.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 增长激素治疗疗法 增长激素治疗
- 生物标记分析 生物标记分析
背景情况:
- 监测胰岛素类生长因子 (IGF) -I 在儿童生长激素 (GH) 治疗期间至关重要.
- 较高的IGF-I总水平引发了人们对潜在的长期健康风险的担忧.
研究的目的:
- 为了比较健康儿童和青少年的生物活性和总IGF-I水平.
- 在接受GH治疗的儿童中评估生物活性和总IGF-I.
主要方法:
- 生物活性IGF-I (KIRA) 的确定的儿科,性别特定的参考范围.
- 比较生物活性IGF-I与总IGF-I,IGF-I/IGFBP-3摩尔比率 (iSYS),以及IGF-I, -II,IGFBP-3,ALS (LC-MS/MS) 的比较.
- 在GH治疗期间评估IGF-I生物活性相对于IGF-I总量.
主要成果:
- 在健康儿童中,生物活性IGF-I与总IGF-I和IGF-I/IGFBP-3正相关.
- 生物活性IGF-I与IGF-II呈现负相关性.
- 与总IGF-I相比,GH治疗的患者中较少比例的生物活性IGF-I水平升高.
结论:
- 生物活性IGF-I水平在接受GH治疗的大多数儿童的参考范围内.
- 对生物活性IGF-I的监测可能有助于优化特定儿科患者亚组的GH剂量.
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