高水平的互白素-6 (IL-6) 与精神运动处理速度的下降有关,但与老年人的执行功能无关:性别特异性影响
Elana M Gloger1,2, Patrick J Smith3, Suzanne C Segerstrom1,4
1Department of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky, United States.
概括
系统性炎症,通过介质素-6 (IL-6) 测量,影响老年女性的精神运动速度,但不影响男性或执行功能. 这突显了认知衰老和炎症的性别特异性差异.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 较高的外周炎症标志物与老年人的认知能力下降有关,尤其是女性.
- 很少有研究探讨了特定性别的炎症-认知联系或人与人之间的影响.
研究的目的:
- 在老年人中调查系统性炎症 (干白素-6) 和认知衰退之间的性别特异关联.
- 区分炎症对认知的稳定 (人与人之间) 和波动 (人内) 影响.
主要方法:
- 对235名老年人 (平均年龄75.1岁) 进行长度研究,每六个月进行认知评估和抽血,长达12年.
- 系统性炎症通过血清中介质素-6 (IL-6) 测量.
- 步道制作测试 (TMT-A,TMT-B,TMT-B-TMT-A) 评估了心理运动速度,任务交换和执行功能. 多级模型分析了关联,控制共变量.
主要成果:
- 在女性中,较高的IL-6平均值与较慢的精神运动速度 (TMT-A) 相关,但男性并非如此.
- 在人体内IL-6波动和认知结果之间没有发现显著的关联.
- 与IL-6水平相关的执行功能或任务切换没有观察到性别适度.
结论:
- 心理运动速度,而不是执行功能,表现出性别特异性对系统性炎症的敏感性.
- 神经衰老中的性别差异需要进一步调查针对认知衰退和衰老的干预措施.
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