预测对情绪障碍的亲认知干预的反应:双极性障碍国际协会针对认知工作组的系统审查
Dimosthenis Tsapekos1, Michail Kalfas1, Johanna M Schandorff2,3
1Centre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Acta psychiatrica Scandinavica
|October 13, 2025
概括
患有重度抑郁症 (MDD) 和双极性障碍 (BD) 的人,最初认知功能较差,往往会通过亲认知干预措施表现出最大的改善. 需要进一步的研究来证实这些预测因素的个性化治疗.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 大型抑郁症 (MDD) 和双极性障碍 (BD) 与影响日常功能的认知缺陷有关.
- 亲认知干预提供了潜力,但产生不一致的结果,可能是由于基线因素.
- 本综述确定了预治疗特征,预测对干预措施的认知反应.
研究的目的:
- 在重大抑郁症和双极性障碍中系统地审查认知改善的预测因素.
- 综合基础因素影响对亲认知干预的反应的证据.
- 为未来的研究提供方法建议.
主要方法:
- 在PubMed/MEDLINE,EMBASE,PsycINFO和Cochrane图书馆进行系统搜索.
- 包括随机对照试验 (RCT),分析认知反应的预测因素.
- 来自40项涉及3864名参与者的研究结果的定性综合.
主要成果:
- 较差的基线认知表现是更大的认知改善的最一致的预测因素.
- 基线抑郁症严重程度,年龄,教育,性别,智商,诊断和药物状况并不是显著的预测因素.
- 发现存在偏差的高风险 (77%),研究之间存在显著的异质性.
结论:
- 较差的基线认知是情绪障碍认知改善的最可靠的预测指标.
- 需要更严格,更强大的研究来确定强大的预测因素.
- 这些发现旨在指导个性化的亲认知治疗策略.
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