通过空气空间扩散的瘤和内脏性肺部侵袭的存在可能会增加非小细胞肺癌中瘤复发的风险
Joshua R Brady1, Brittany Walker1, Jocelyn C Zajac1
1Department of Surgery, University of Wisconsin Hospitals and Clinics, Madison, WI, USA.
概括
肺癌中通过空气空间 (STAS) 传播的瘤和内脏膜入侵 (VPI) 的联合存在不会影响整体生存率. 然而,这种组合显著增加了复发的风险.
科学领域:
- 肺部医学 肺部医学
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 通过空气空间传播的瘤 (STAS) 和内脏膜入侵 (VPI) 是非小细胞肺癌 (NSCLC) 的负预后指标.
- STAS和VPI同时存在的潜在复合预后效应尚不清楚.
研究的目的:
- 研究STAS和VPI对NSCLC患者的整体存活率和复发的综合预后影响.
- 分析STAS和VPI的同时发生与肺切除后患者结局之间的关联.
主要方法:
- 对421名为NSCLC进行肺切除的成年患者 (2018-2022) 的回顾性队列分析.
- 仅STAS,仅VPI或STAS和VPI的患者之间的基线特征的比较.
- 卡普兰-梅尔法用于比较整体生存率和累计复发率.
主要成果:
- 在421名患者中,34名 (8%) 患有STAS和VPI.
- 结合STAS和VPI与增加的吸烟包年,更大的瘤大小和淋巴血管入侵有关.
- 在STAS/VPI组合患者与仅有一种或两种都没有患者之间,没有观察到总生存时间的显著差异 (p=0.190).
- 在STAS和VPI患者中发现复发的累积发病率显著增加 (p=0.001).
结论:
- 在NSCLC中STAS和VPI的同时存在似乎不会对整体存活率产生负面影响.
- STAS和VPI的组合可能会显著增加癌症复发的风险.
- 需要进一步的研究,以阐明与联合STAS和VPI相关的复发风险增加背后的机制.
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