相关实验视频

Updated: Jan 15, 2026

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Analyzing the Effects of Stromal Cells on the Recruitment of Leukocytes from Flow

Published on: January 7, 2015

介酶体 stromal 细胞诱导中性粒细胞聚合和细胞外囊泡风暴系统性红斑狼

Qianmin Ou¹, Luhan Niu¹, Dandan Wang²

¹South China Center of Craniofacial Stem Cell Research, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.

Signal transduction and targeted therapy

|October 13, 2025

概括

狼 (SLE) 中介细胞 stromal cell (MSC) 疗法通过触发中性粒细胞聚合来起作用,从而产生细胞外囊泡 (EV) 风暴. 这种EV风暴对于免疫耐受性和预测治疗成功至关重要.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
再生医学是一种再生医学.

背景情况:

介酶体 stromal 细胞 (MSCs) 在诸如系统性红斑狼 (SLE) 等自身免疫性疾病中表现出治疗潜力.
在MSC治疗效果的基础上的精确机制,特别是在SLE中,仍然不完全理解.

研究的目的:

阐明MSC移植在SLE治疗中的详细治疗机制.
调查内源性细胞外囊泡 (EV) 在MSC介导的SLE治疗中的作用.

主要方法:

在SLE模型和患者中研究了MSC移植效应.
分析了中性粒细胞聚合,EV风暴生成以及相关的分子通路 (TNFα/ICAM-1/Rab11b,DHA/LILRB4/STAT5/STAT3).
评估了EV风暴封锁对治疗疗效的影响.

主要成果:

MSC移植诱导骨髓中性粒细胞聚合,通过TNFα/ICAM-1/Rab11b轴导致内源性EV风暴.
阻止EV风暴取消了MSC在SLE的治疗益处;EV风暴水平与治疗疗效有积极的相关性.
EV风暴使Th17和T调节细胞平衡,通过DHA/LILRB4/STAT5/STAT3通路促进免疫耐受性和缓解.

结论:

对于SLE的MSC治疗包括从聚合中性粒细胞诱导内源性EV风暴,这对于免疫耐受性和疾病缓解至关重要.
受体EV风暴是MSC疗效的关键调解者,可以作为SLE治疗成功的预测生物标志物.

更多相关视频

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation

Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation

Published on: June 28, 2024

相关概念视频

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...