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Updated: Jan 15, 2026

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MAPL调节了从溶酶体中通过气皮胺介导的mtDNA释放,以驱动热性细胞死亡

Mai Nguyen1,2, Jack J Collier1,2, Olesia Ignatenko1,2

  • 1Department of Neurology and Neuroscience, Montréal Neurological Institute, McGill University, Montréal, Quebec, Canada.

Nature cell biology
|October 13, 2025
PubMed
概括

线粒体定蛋白联酶 (MAPL) 通过将线粒体DNA移动到 lysosomes,触发炎症性细胞死亡 (pyroptosis). 这一途径与像帕金森氏症这样的神经退行性疾病有关.

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