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相关概念视频

Population Growth00:57

Population Growth

27.8K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
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Principle of Virtual Work: Problem Solving01:13

Principle of Virtual Work: Problem Solving

1.6K
The principle of virtual work is an essential concept in the field of mechanics and engineering. This is used to solve problems related to the equilibrium of a structure or system. It is based on the assumption that if a system is in equilibrium, the work done by all the forces during a virtual displacement is zero. This principle is applied by considering virtual displacements of the system and the corresponding work done by internal and external forces.
To apply the principle of virtual work,...
1.6K
Virtual Work01:20

Virtual Work

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The principle of virtual work states that if a body is in static and dynamic equilibrium, then the sum of all the virtual work done by all external forces and couple moments for any given virtual displacement must be zero.
In static equilibrium, a body can experience an imaginary or virtual movement, such as displacement or rotation. The virtual work done by a force is equal to the dot product of force and virtual displacement in the direction of the force. When it comes to virtually rotating a...
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Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

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Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
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Stratified Sampling Method01:16

Stratified Sampling Method

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Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a stratified sample, divide the population into groups called strata and then take a...
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Virtual Work for a System of Connected Rigid Bodies01:06

Virtual Work for a System of Connected Rigid Bodies

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Virtual work is a powerful method used to solve problems involving several connected rigid bodies. When the system is in equilibrium, virtual work is zero. This allows the calculation of the resulting forces when a system undergoes a virtual displacement. When attempting to analyze such a system, first, use a free-body diagram, where an independent coordinate represents the configuration of the links, and mark its deflected position resulting from the positive virtual displacement.
Next,...
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相关实验视频

Updated: Jan 15, 2026

Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
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Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm

Published on: December 9, 2012

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虚拟人口发展的代理指导工作流

Lu Huang1,2,3, Yinbo Chen4, Satyendra Suryawanshi5

  • 1Clinical Pharmacology, Pharmacometrics and Bioanalysis, Bristol Myers Squibb, Princeton, NJ, USA. dr.luhuang@gmail.com.

The AAPS journal
|October 13, 2025
PubMed
概括

定量系统药理 (QSP) 模型加速药物开发. 一个新的代理引导工作流显著加快了虚拟群体 (VPops) 校准临床数据的速度,提高了效率.

关键词:
凸凸的优化优化免疫瘤学 免疫瘤学患病率重量为流行率重量.定量系统药理学 药理学虚拟人口是虚拟的人口.

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A Networked Desktop Virtual Reality Setup for Decision Science and Navigation Experiments with Multiple Participants
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Visualizing Hyporheic Flow Through Bedforms Using Dye Experiments and Simulation
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Visualizing Hyporheic Flow Through Bedforms Using Dye Experiments and Simulation

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相关实验视频

Last Updated: Jan 15, 2026

Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm
11:53

Spatial Multiobjective Optimization of Agricultural Conservation Practices using a SWAT Model and an Evolutionary Algorithm

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A Networked Desktop Virtual Reality Setup for Decision Science and Navigation Experiments with Multiple Participants
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A Networked Desktop Virtual Reality Setup for Decision Science and Navigation Experiments with Multiple Participants

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科学领域:

  • 制药指标 (Pharmacometrics) 是一个指标.
  • 计算生物学 计算生物学
  • 药物开发 药物开发

背景情况:

  • 定量系统药理 (QSP) 模型对于药物开发至关重要,有助于探索患者变异性和预测治疗结果.
  • QSP工具箱促进了对各种临床数据进行校准的虚拟人群 (VPops) 的开发.
  • 当前的VPop校准工作流程通过反复优化流行度权重来减缓,以最大限度地提高适度良性 (GOF) 函数,标记为p.

研究的目的:

  • 为 QSP 模型开发更快的 VPop 校准工作流.
  • 引入代理的合适性 (GOF) 功能,以简化优化过程.
  • 提高生成准确匹配临床数据的VPops的效率.

主要方法:

  • 使用代理GOF功能实现代理指导的工作流.
  • 减少代理GOF函数的最大化,以最小化凸的二次目标函数.
  • 代理引导工作流与原始p引导工作流的速度和效率的比较.

主要成果:

  • 代理引导的工作流成功地生成了具有高适合性 (p-fit) 的VPops,而无需持续最大化p.
  • 新的工作流大大减少了VPop校准所需的计算时间.
  • 代理引导校准比原来的p引导方法快得多.

结论:

  • 代理指导的工作流为QSP模型开发中的VPops校准提供了显著的速度改进.
  • 这种方法提高了在药物开发管道中使用QSP模型的效率.
  • 该方法有助于创建可靠的VPops来探索患者的变化和预测治疗反应.