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帕金森病中与嗅觉相关的大脑区域的结构和扩散成像:临床进展的预测因素

Seyyed Mohammad Hosseini¹, Ahmadreza Sohrabi-Ashlaghi¹, Shahriar Kolahi¹

¹Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Scientific reports

|October 13, 2025

概括

早期帕金森病 (PD) 在嗅觉大脑区域呈现渐进的神经退行,影响认知. 基线MRI和生物标志物预测了PD患者未来的认知衰退和疾病严重程度.

科学领域:

神经成像是一种神经成像.
神经学神经学
生物标志物生物标志物

背景情况:

嗅觉功能障碍是帕金森病 (PD) 的一个常见的非运动症状.
与嗅觉相关的大脑区域的神经退行性变化是由PD中的结构和扩散MRI建议的.
纵向成像数据对于了解PD进展至关重要.

研究的目的:

在四年内纵向探索早期PD中嗅觉相关区域的结构和扩散成像变化.
研究基线成像,流体生物标志物和随后的认知和临床变化之间的关系.
为了确定PD进展的潜在预后标志物.

主要方法:

来自帕金森病进展标记计划 (PPMI) 的97名早期PD患者的分析,随访时间为4年.
使用T1加权的MRI和扩散张力成像 (DTI) 来评估与嗅觉相关的区域.
评估了结构和扩散措施,流体生物标志物,认知和临床评估.

主要成果:

在杏仁体,轨道前皮层 (OFC),胰岛和丘脑的基线平均扩散度 (MD) 与认知变化相关.
基线杏仁体体积,内腔和OFC厚度预测了认知和UPDRS得分变化.
血清神经丝-光链水平预测了认知得分的变化.
纵向分析显示,体MD增加,杏仁体,胰岛体,OFC和脑内皮层的体积/厚度减少.
胸膜扩散指标预测了认知能力的恶化.

结论:

嗅觉相关的大脑区域在早期的PD中经历渐进的神经退行.
这种神经退行导致认知能力下降和疾病严重程度的增加.
基线成像和流体生物标志物显示出PD的预后工具的潜力.

关键词:

认知障碍认知障碍是一种认知障碍.扩散张力成像的成像方法纵向研究是一项纵向研究.嗅觉大脑区域是嗅觉大脑区域.帕金森病是帕金森氏症的一种疾病.权重为T1的核磁共振成像

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