抑郁症和腹部肥胖对中老年人群认知功能的附加效应:来自跨国队列的证据
Ruiqi Wang1, Yalin Chen1, Kayla M Teopiz2
1Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University, Chongqing, 400715, People's Republic of China.
BMC medicine
|October 14, 2025
概括
这项研究发现,腹部肥胖和抑郁症独立且附加地影响老年人的认知功能. 减少腹部肥胖可能会改善抑郁症患者的认知能力.
科学领域:
- 老年学与公共卫生
- 神经科学和认知科学 神经科学和认知科学
- 代谢和内分泌疾病 代谢和内分泌疾病
背景情况:
- 研究肥胖/腹部肥胖和抑郁症之间的相互作用对于理解认知衰退至关重要.
- 以前的研究还没有完全阐明联合轨迹和长期认知关联.
研究的目的:
- 检查肥胖/腹部肥胖和抑郁症的联合轨迹.
- 评估这些联合轨迹与四个多样化,全国代表性队列的认知功能之间的关联.
主要方法:
- 利用来自中国,英国,美国和墨西哥45岁以上的114,633名成年人的数据.
- 采用Kml3D集群识别肥胖和抑郁的联合轨迹.
- 应用通用估计方程 (GEE) 来分析与认知功能的关联.
主要成果:
- 抑郁症和肥胖症的基线并发症与较差的认知表现有关.
- 抑郁的轨迹,无论肥胖,都与所有队伍的认知能力下降有关.
- 腹部肥胖,特别是腰部与身高的比较高,在与抑郁症并发时,显著导致认知能力下降.
结论:
- 腹部肥胖和抑郁症对老年人的认知有独立的附加效应.
- 针对多余脂肪,特别是腹部肥胖的干预措施可能为抑郁症患者提供认知效益.
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