在支气管镜检查期间对老年患者进行雷米马佐拉姆的可行性和安全性评估:单中心随机对照试验
Yaqin Huang1, Yang Yu2, Weiping Lei1
1Department of Anesthesia, Affiliated Hangzhou First People´s Hospital, School of Medicine, Westlake University, Hangzhou, China.
BMC anesthesiology
|October 14, 2025
概括
与芬太尼结合的雷米马佐拉姆为接受光纤支气管镜检查的老年患者提供了安全有效的镇静选择,与米达佐拉姆相比,显示出更好的稳定性和更快的恢复.
科学领域:
- 麻醉学 麻醉学
- 老年医学 老年医学
- 肺部病理学 肺部病理学
背景情况:
- 光纤支气管镜检查是一种至关重要的诊断工具,在COVID-19大流行期间尤为重要.
- 适当的中度镇静对于患者的舒适性和程序的成功至关重要.
- 在老年人群中评估新型镇静剂是非常重要的,因为与年龄相关的生理变化.
研究的目的:
- 评估雷米马佐拉姆在接受光纤支气管镜检查的老年患者中适度镇静的可行性和安全性.
- 为了比较基于雷米马佐拉姆的镇静与米达佐拉姆和局部麻醉的疗效和安全性.
主要方法:
- 一个单中心,随机,受控试验,涉及105名接受光纤支气管镜检查的老年患者.
- 患者被分配到三个组:雷米马佐拉姆+芬太尼,米达佐拉姆+芬太尼,或仅局部麻醉.
- 主要结局包括生命体征,镇静水平和不良事件;次要结局涉及发病和恢复时间以及满意度.
主要成果:
- 与单独局部麻醉相比,雷米马佐拉姆和米达佐拉姆组显示出明显更稳定的生命体征和较低的高血压率.
- 与米达佐拉姆相比,雷米马佐拉姆的发病和恢复时间较短.
- 与局部麻醉组相比,雷米马佐拉姆和米达佐拉姆组的患者和操作人员满意度更高.
结论:
- 静脉注射雷米马佐拉姆 (0.2 mg/kg) 与芬太尼结合,在光纤支气管镜检查期间为老年患者提供有效和安全的镇静作用.
- 这种疗法在更快的发病和恢复方面具有优势,同时具有稳定的生理参数.
- 雷米马佐拉姆在这种患者群体中代表了适度镇静的有希望的替代品.
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