富血小板纤维素 (PRF) 的止痛作用:一个系统的审查
Nathan E Estrin1,2,3, Troy B Tran2, Paras Ahmad3
1The University of Iowa College of Dentistry and Dental Clinics, Iowa City, Iowa, USA.
Periodontology 2000
|October 14, 2025
概括
富含血小板纤维素 (PRF) 在各种医疗和牙科手术中显著减少术后疼痛和止痛药的使用. 这次审查突出了PRF的重点.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 临床牙科 临床牙科
背景情况:
- 富含血小板纤维素 (PRF) 是第二代自身血小板缩剂,以其抗炎和再生性质而闻名.
- 虽然PRF在组织愈合中的作用已经确立,但其止痛潜力需要进一步研究.
研究的目的:
- 系统地审查与PRF相关的疼痛结果在医学和牙科领域的人类临床研究中.
- 评估与PRF使用相关的二次结果,包括胀,生活质量和止痛药消耗.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Google Scholar) 中进行了系统的文献搜索.
- 包括比较性临床试验,评估PRF与非PRF对照,以疼痛为主要结果.
- 分析了200项研究,涵盖了各种程序,但因异质性而排除了元分析.
主要成果:
- 几乎所有研究都报告了与对照组相比,PRF组的疼痛和胀减少.
- 随着PRF的使用,疼痛缓解剂使用的显著减少和患者报告结果的改善被观察到.
- 已知高疼痛的手术,如第三牙提取,显示明显减少疼痛 (72%-85%) 和减少止痛药的需求 (87.5%) 与PRF.
结论:
- PRF的自身性质和持续的生物活性因子释放可能有助于减少炎症,增强愈合和改善患者舒适度.
- 需要进一步进行精心设计的,采用标准化措施的比较研究,以充分阐明PRF的治疗潜力,并指导临床实践.
更多相关视频
14:38Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
Published on: January 4, 2019
19.2K
07:51Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
Published on: March 19, 2018
9.6K
相关概念视频
Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors
1.1K
Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
1.1K
Formation of the Platelet Plug
8.7K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
8.7K
Clot Retraction and Fibrinolysis
8.4K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
8.4K
Peripheral Artery Disease III: Interprofessional Care
242
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
242
