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在使用聚乙烯微塑料后,MiR-532-5p减轻认知缺陷和内分泌网膜压力

Leila Mohammadi¹, Tourandokht Baluchnejadmojarad¹, Mina Goudarzi¹

¹Department of Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Environmental toxicology

|October 14, 2025

概括

聚乙烯微塑料通过引起氧化应激和神经炎症来损害老鼠的学习和记忆. 微RNA-532-5p治疗扭转了这些认知缺陷,提供了一个潜在的治疗策略.

科学领域:

环境毒理学环境毒理学
神经科学是一个神经科学.
分子生物学分子生物学

背景情况:

微塑料污染构成了全球环境威胁.
微塑料对认知功能,特别是学习和记忆的影响尚不清楚.
研究微RNAs在调解这些效应中的作用至关重要.

研究的目的:

为了确定聚乙烯微塑料 (PS-MPs) 对大鼠学习和记忆的影响.
阐明miR-532-5p在PS-MP引起的认知缺陷中的作用.
确定这些影响背后的分子机制.

主要方法:

雄性大鼠被口服PS-MPs (30毫克/公斤8周).
在治疗组中,miR-532-5p是通过脑内静脉输入 (ICV) 给药的.
用新型对象歧视,Y迷宫和巴恩斯迷宫测试来评估认知功能.
分析了海马组织的氧化应激,神经炎症,亡,烧亡以及信号通路标记物.

主要成果:

暴露于PS-MP显著损害了老鼠的学习和记忆.
PS-MPs增加了氧化应激 (MDA,蛋白质碳基,酸盐),神经炎症 (TNFα,NLRP3,Caspase 1,GFAP),亡 (caspase 3) 和ER应激 (PERK/GRP78/CHOP通路激活) 的标志物.
PS-MPs降低了抗氧化剂标记物 (SOD,甲酶),SIRT1,BDNF水平,并禁用了Wnt/β-catenin和PI3K/Akt通路.
通过ICV注射miR-532-5p可以逆转这些有害影响.

结论:

通过在海马体中促进氧化应激,神经炎症,亡,烧亡和ER应激,PS-MPs诱导认知和记忆缺陷.
miR-532-5p作为一种保护剂,通过其抗氧化,抗炎和抗火性质恢复认知功能.
miR-532-5p是缓解微塑料诱导的神经毒性的潜在治疗标.

关键词:

细胞内膜网膜的压力应激学习和记忆的学习和记忆.在 miR-532-5p 中.氧化应激是一种氧化应激.聚乙烯微塑料的微塑料.

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