在BCR:ABL1阳性慢性髓性白血病患者中,伊马替尼诱导的甲状腺功能障碍:索卡尔得分作为预测因素
Ibrahim Oluwaseun Ahmed1, Muritala Abiola Asafa2, Babatunde Ayodeji Adeagbo3
1Department of Haematology and Blood Transfusion, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria.
概括
高索卡尔得分和BCR::ABL1转录比率预测慢性髓性白血病 (CML) 患者的甲状腺功能障碍. 早期识别这些风险因素可以帮助管理这种不利影响.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 药理学 药理学 是一个学科.
背景情况:
- 甲状腺功能障碍是伊马替尼治疗中已知的副作用之一.
- 在慢性髓性白血病 (CML) 患者中,伊马替尼布诱导的甲状腺功能障碍的危险因素尚不清楚.
研究的目的:
- 为了研究基线参数作为预测甲状腺功能障碍在imatinib-naïve CML患者.
- 为了确定与伊马替尼布诱导的甲状腺功能障碍相关的特定风险因素.
主要方法:
- 一项对50名前不服用伊马替尼布的CML患者进行的纵向研究.
- 血清中TSH,FT3和FT4水平被监测了6个月.
- 评估了包括BCR:ABL1比率,Sokal,Hasford和EUTO分数在内的基线参数.
主要成果:
- 甲状腺功能障碍发生在7名患者中 (14%) 在6个月内.
- 在患有甲状腺功能障碍的患者中观察到较高的Sokal和Hasford分数.
- 血清TSH与索卡尔得分和BCR:ABL1比率正相关.
结论:
- 诊断时高索卡尔得分和升高的BCR:ABL1转录比率是伊马替尼布诱导的甲状腺功能障碍的预测因素.
- 这些发现可能有助于早期风险评估和CML患者甲状腺功能障碍的管理.
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