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扩散大B细胞淋巴瘤 - - 来自印度东部一家三级医院的经验

Tuphan Kanti Dolai¹, Kaustav Ghosh¹, Swapnodeep Sarkar²

¹Department of Hematology, Nilratan Sircar Medical College and Hospital, Kolkata, India.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

|October 14, 2025

概括

这项研究分析了580名印度扩散型大B细胞淋巴瘤 (DLBCL) 患者,这些患者接受了基于rituximab的化疗. 生殖中心B细胞 (GCB) 类型显示出比激活B细胞 (ABC) 类型更好的结果.

科学领域:

血液学血液学血液学
在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

扩散性大B细胞淋巴瘤 (DLBCL) 是一种异质的非霍奇金淋巴瘤 (NHL).
基于rituximab的化疗改善了DLBCL患者的治疗结果.
了解DLBCL亚型和预后因素对于治疗优化至关重要.

研究的目的:

根据细胞来源,临床特征和结果分析印度DLBCL患者数据.
评估基于rituximab的化疗在不同DLBCL亚型中的有效性.
确定与DLBCL治疗反应和生存相关的因素.

主要方法:

从2016年到2023年对580名DLBCL患者进行了回顾性观察研究.
原始细胞通过免疫组织化学测定,使用汉斯算法.
临床特征,国际预后指数 (IPI) 风险和治疗结果 (反应,无进展生存,总生存) 的分析.

主要成果:

活性B细胞 (ABC) 亚型是最常见的 (平均年龄55岁).
第四阶段疾病 (41%) 和高中期风险 (36%) 是普遍存在的.
生殖中心B细胞 (GCB) 的完全响应率为73%,ABC类型为43%.
两年无进展生存率 (PFS) 为GCB的87.6%,为ABC的70.5%.
两年整体生存率 (OS) 为GCB的87.7%,为ABC的73.5%.

结论:

印度DLBCL患者的治疗结果因细胞来源 (GCB与ABC) 有显著差异.
与ABC类型相比,GCB类型的DLBCL显示出更高的反应率和生存率.
女性性别,晚期,高IPI,体积较大的疾病和非R-CHOP化疗等因素与较差的结果有关.

关键词:

激活的B细胞完整的响应反应完整的响应反应扩散型大B细胞淋巴瘤基于利图西马布的化疗疗法

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