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pH调节脂质膜中的粉样-β42构造:循环二元化,拉曼光谱和分子动力学模拟的证据

Khlood A A Abdeljawaad1,2,3, Yersultan Arynbek1,4,5, Kahramon Mamatkulov1

  • 1Frank Laboratory of Neutron Physics, Department of Raman Spectroscopy, Joint Institute for Nuclear Research, Dubna, Russia.

Journal of biomolecular structure & dynamics
|October 14, 2025
PubMed
概括

pH值显著改变神经元膜中的粉样β42 (Aβ42) 结构. 酸性条件促进阿尔法螺旋形状,而中性和性pH偏好随机线圈结构,影响阿尔茨海默病的进展.

关键词:
Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42 Aβ42模拟MDMD的模拟拉曼光谱法 拉曼光谱法一个圆形的二重化.二级结构是二级结构的二次结构.

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