对于具有精神病特征的抑郁情节的治疗, (Es) 胺:系统性审查
Henrique Castro Santos1,2,3, Alexandra Rodrigues4,5, Tiago Machado6
1Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, https://ror.org/0220mzb33King's College London, London, UK.
BJPsych open
|October 14, 2025
概括
胺和胺对治疗具有精神病特征的抑郁症,改善情绪和精神病症状,具有良好的安全性,有希望. 由于研究的局限性,需要进一步的研究来证实这些发现.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 抑郁症中的精神病症状与较差的结果和有限的治疗选择有关.
- 胺和胺是有效的抗抑郁药物,但它们在患有精神病特征的患者中的使用尚未得到充分研究.
研究的目的:
- 系统地审查胺和胺的疗效和安全性,用于治疗单极性和双极性障碍中具有精神病特征的抑郁发作.
- 评估对抑郁和精神病症状和不良事件的影响.
主要方法:
- 在PubMed,Ovid和Web of Science数据库中进行了系统的文献搜索,直到2023年11月.
- 包括的研究报告了在患有精神病性抑郁情节的患者中使用胺或胺.
- 主要结局是抑郁和精神病症状的变化以及不良事件发生率.
主要成果:
- 分析了10项涉及79名患者的研究 (60例单极性,19例具有精神病特征的双极性抑郁症).
- (Esk) 胺治疗显示蒙哥马利-阿斯伯格抑郁症评分表得分显著降低,单极抑郁症的缓解率高达50%.
- 副作用通常是轻微的和短暂的;没有报告过渡到躁狂或精神病恶化,一些研究显示精神病症状有所改善.
结论:
- 目前的证据表明 (es) ketamine具有抗抑郁作用,并且对具有精神病特征的抑郁症具有有利的安全性.
- 包含的研究中高异质性和偏差风险需要谨慎.
- 需要进一步严格的临床试验来验证这些初步发现.
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