关于对心力衰竭患者进行药物治疗优化的建议的实施: HEROES研究计划住院治疗心力衰竭患者: HEROES研究
Agata Galas1, Robert Morawiec2, Agata Tymińska3
1Department of Cardiology and Internal Diseases, Military Institute of Medicine – National Research Institute, Warszawa, Poland. agalas@wim.mil.pl
Polish archives of internal medicine
|October 14, 2025
概括
在住院患者中,指南导向医学治疗 (GDMT) 优化改善了心力衰竭 (HF) 药物使用. 然而,达到高剂量GDMT的目标仍然不够理想,这表明需要改进策略.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 优化指南导向医学疗法 (GDMT) 对于改善心力衰竭 (HF) 患者预后至关重要.
- 对HF患者的慢性护理管理侧重于增强GDMT.
- 在住院期间,在高炎患者中实施GDMT建议是研究的一个关键领域.
研究的目的:
- 评估GDMT优化建议在心力衰竭住院患者的实施情况.
- 专门评估左心室喷射分数 (LVEF) 减少的患者的GDMT优化.
主要方法:
- 来自HEROES研究 (波兰心脏病学会心力衰竭观察研究) 的412名已知LVEF患者的分析.
- 包括41个波兰中心接受预定住院治疗的患者.
- 从2022年4月到2024年5月收集的数据.
主要成果:
- 在降低LVEF (HFrEF) 的HF患者中,药物使用 (ARNI/ACEI/ARB,β-阻断剂,MRA,SGLT2i) 从入院到出院时增加.
- 个别GDMT支柱的优化率低于40%.
- 只有22.3%的患者达到4支柱GDMT目标剂量的50%.
结论:
- 在 HEROES 登记册中,超过 80% 的 HFrEF 患者通过 4 支柱 GDMT 获得了出院.
- 在HF患者中达到高剂量GDMT的目标水平仍然不够理想.
- 调查结果突出了GDMT实施中的国家差异,以及对剂量优化策略的需求.
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