菌突变菌 (Streptococcus mutans) 化毒性分子调节的轨迹和趋势:一个图书法分析分析
Yi Yin1, Sishi Dong1,2, Xinze Wu1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Future microbiology
|October 14, 2025
概括
对Streptococcus mutans (S. mutans) 毒性的研究揭示了向复杂的调控网络和翻译后修改的转变. 这项研究绘制了病原性毒性研究的演变图,确定了未来抗病策略的关键趋势.
科学领域:
- 微生物学 微生物学
- 分子生物学分子生物学
- 牙科研究 牙科研究
背景情况:
- 牙损伤是一种全球性慢性疾病,是由突变性菌株 (S. mutans) 引起的.
- S. mutans 具有多方面的毒性属性,有助于其造潜力.
- 了解S. mutans病毒性的分子调节对于开发有针对性的预防和治疗至关重要.
研究的目的:
- 绘制研究轨迹并确定S. mutans cariogenic毒性分子调节的未来趋势.
- 提供对该领域发展和热点的系统概述.
- 为新型抗病策略提供理论基础.
主要方法:
- 对470篇出版物 (1994-2024) 的图书识别和科学识别分析.
- 利用科学网络核心数据收集数据.
- 使用分析平台CiteSpace,VOSviewer和R进行可视化和热点识别.
主要成果:
- 该领域已经从基本的基因/代谢研究演变为复杂的监管网络 (定数感应,双组件系统,环境适应).
- 最近的研究强调了转录后和翻译后的修改 (氨酸乙化,氨酸化,氨酸化).
- 这些修饰调节毒性因子表达,应激反应和生物膜动态.
结论:
- 这项研究提供了S. mutans cariogenic virulence研究趋势的第一个系统概述.
- 确定了分子调节研究中的关键热点和新兴趋势.
- 为未来的调查和开发新型抗虫策略提供了基础.
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