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Updated: Jan 15, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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多循环框架的分离构造,由顺序Ru-催化 [2 + 2 + 2] 循环添加丁和Pd/Norbornene介导的Catellani类型无效化实现

Yoshihiko Yamamoto1, Yutaro Hayashi1, Kenichi Yoshimura1

  • 1Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.

Organic letters
|October 14, 2025
PubMed
概括

催化循环添加会产生双循环的. 然后,催化无效形成复杂的多环分子,揭示了C-H激活作为速率限制.

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