在连接组织疾病中查肺高血压:文献综述和多学科共识声明
Alper Sarı1, Duygu Temiz Karadağ2, Mustafa Erdoğan3
1Department of Rheumatology, Etlik City Hospital, Ankara, Türkiye.
Anatolian journal of cardiology
|October 14, 2025
概括
有结缔组织疾病 (CTD) 的患者面临更高的肺高血压 (PH) 风险. 通过查及早检测PH,特别是系统性硬化症 (SSc) 患者的心声扫描,可以改善结果.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 医学查 医学查
背景情况:
- 连接组织疾病 (CTD) 增加了肺高血压 (PH) 和肺动脉高血压 (PAH) 的风险.
- 在CTD患者中早期检测PH与改善结果有关.
- 目前CTD中PH的查方法包括成像,生物标志物和肺功能测试.
研究的目的:
- 制定基于共识的建议和CTD患者PH的查算法.
- 综合从CTD中PH查方法的系统文献综述中得到的证据.
- 为高风险CTD人群中早期PH检测提供指导.
主要方法:
- 一个多学科的共识小组 (10位风湿病学家,4位心脏病学家,3位肺病学家) 被召集.
- 对PubMed数据库进行了系统的文献审查,以确定相关研究.
- 基于文献数据和专家意见,达成了共识.
主要成果:
- 通过文献审查确定了33篇相关文章.
- 在研究定义,截止值和患者症状状况方面注意到了显著的异质性.
- 开发了一种对系统性硬化症 (SSc) 和SSc重叠CTD患者PH查的回声心脏学优先考虑的算法.
结论:
- 建议使用心声扫描来查和早期检测SSc患者和SSc重叠特征患者的PH.
- 有限的数据阻止了对无症状CTD患者的建议,没有SSc重叠.
- 需要进一步的研究,为更广泛的CTD人群制定查指南.
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