相关实验视频
Updated: Jan 15, 2026

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
1.0K
[COVID后综合征患者的炎症性类风湿性疾病]
N Kippenbroek1, A Stölting1, D Schröder2
1Klinik für Rheumatologie und Immunologie, Medizinische Hochschule Hannover, Carl Neuberg Str. 1, 30625, Hannover, Deutschland.
Zeitschrift fur Rheumatologie
|October 14, 2025
概括
后COVID综合征 (PCS) 与类风湿性疾病有共同的症状. 虽然6.25%的PCS患者表现出炎症性类风湿病 (IRD) 的迹象,但如果没有进一步的风险因素,就不建议单独对PCS进行例行类风湿学评估.
科学领域:
- 类风湿病学 类风湿病学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 后COVID综合征 (PCS) 在SARS-CoV-2感染后呈现长期症状.
- 在PCS和类风湿性疾病之间存在显著的症状和生物标志物重叠,特别是原病.
- 缺乏差异化生物标志物和关于德国PCS患者风湿性疾病患病率的稀缺数据.
研究的目的:
- 研究PCS患者炎症性类风湿性疾病 (IRD) 的患病率和特征.
- 识别潜在的生物标志物,区分PCS与IRD和没有IRD.
- 评估PCS和类风湿性疾病之间的症状重叠.
主要方法:
- 通过DEFEAT-Corona平台,通过DEFEAT-Corona平台招募了80名PCS患者,没有先前的IRD诊断.
- 分析了典型的PCS和类风湿病投诉.
- 进行了全面的实验室分析,包括C反应蛋白 (CRP) 和红细胞沉率 (ESR).
主要成果:
- 炎症性类风湿性疾病 (IRD) 在6.25%的PCS患者中被怀疑或确诊.
- 没有IRD的PCS患者表现出相当大的症状重叠与类风湿性疾病.
- 在疑似IRD的PCS患者中,升高的CRP和ESR水平明显更常见.
结论:
- 在没有先前IRD怀疑的患者中,PCS和类风湿性疾病之间存在很高的症状重叠.
- 在PCS患者中,IRD的风险可能会增加.
- 没有额外的风险因素,如CRP升高或关节炎,通常不需要进行PCS的常规风湿学评估.
相关概念视频
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
482
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
482
Rheumatic Heart Disease I: Introduction
433
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
433
Rheumatic Heart Disease III: Medical Management
285
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
285
Myocarditis III: Medical Management
174
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
174
Rheumatic Heart Disease IV: Nursing Management
268
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
268
Myocarditis II: Clinical Features and Diagnostic Tests
265
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
265

