上升大动脉-下降大动脉外部/内部距离指数作为预测胎儿大动脉完全转移的潜在新方法:试点研究
Qi Yang1,2, Yanping Ruan1,2, Xiaoyan Gu1,2
1Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Pediatric cardiology
|October 14, 2025
概括
上升性大动脉 (AAO) - 下降性大动脉 (DAO) 外部/内部距离指数 (ODI/IDI) 有效预测胎儿大动脉的完全转移 (D-TGA). 这一指数显示了在区分D-TGA与正常胎儿及其亚型方面的高灵敏度和特异性.
科学领域:
- 胎儿心脏病学 胎儿心脏病学
- 医学成像医学成像
- 遗传性心脏缺陷是一种先天性心脏缺陷.
背景情况:
- 大动脉的胎儿完全转移 (D-TGA) 是一种严重的先天性心脏缺陷.
- 准确的产前诊断对于及时干预和改善结果至关重要.
- 需要新的成像指数来增强诊断能力.
研究的目的:
- 评估胎儿D-TGA上升性大动脉 (AAO) -下降性大动脉 (DAO) 外部/内部距离指数 (AAO-DAO ODI/IDI) 的预测值.
- 评估AAO-DAO ODI/IDI对D-TGA和正常胎儿进行区分的能力.
- 为了在D-TGA胎儿中比较AAO-DAO ODI/IDI,有完整的腹腔隔膜 (D-TGA-IVS) 与那些有腹腔隔膜缺陷 (D-TGA-VSD) 的胎儿.
主要方法:
- 对D-TGA和妊娠年龄匹配的正常胎儿的回顾性研究.
- 使用超声波测量AAO-DAO外部/内部距离 (OD/ID) 和DAO直径.
- 使用接收机运行特征 (ROC) 曲线计算AAO-DAO ODI/IDI并进行分析.
主要成果:
- 与正常对照组相比,D-TGA胎儿的AAO-DAO ODI/IDI显著高于正常对照组 (P < 0.001).
- 与D-TGA-VSD胎儿相比,D-TGA-IVS胎儿的AAO-DAO ODI/IDI也更高 (P < 0.001).与D-TGA-VSD胎儿相比,D-TGA-IVS胎儿的AAO-DAO ODI/IDI也更高 (P < 0.001).与D-TGA-VSD胎儿相比,D-TGA-IVS胎儿的AAO-DAO ODI/IDI也更高.
- 经过ROC分析,D-TGA的区别很好 (ODI AUC: 0.998,IDI AUC: 0.999) 和D-TGA亚型的区别很公平 (ODI AUC: 0.807,IDI AUC: 0.814).
结论:
- AAO-DAO ODI/IDI 是对胎儿D-TGA的高度敏感和特定的预测指标.
- 这个指数可以有效地区分D-TGA和正常胎儿,并有助于区分D-TGA亚型.
- 该AAO-DAO ODI/IDI代表了一个有价值的工具,用于D-TGA的产前诊断.
相关概念视频
The Aorta
2.5K
The aorta is the largest artery in the human body. It originates from the left ventricle of the heart and extends down to the abdomen, where it splits into two smaller arteries. Structurally, it can be divided into four main parts: the ascending aorta, the aortic arch, the thoracic aorta, and the abdominal aorta.
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...
2.5K
Thoracic Aorta
1.5K
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
1.5K
Abdominal Aorta
2.1K
Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
The celiac trunk, a singular artery, divides into the left gastric artery, which...
2.1K
Fetal Circulation
2.6K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.6K
The Arch of Aorta
1.6K
The coronary arteries, originating from the ascending aorta, bifurcate from two sinuses located within the ascending aorta. Positioned just above the aortic semilunar valve, these sinuses house essential aortic baroreceptors and chemoreceptors, crucial for maintaining cardiac function. The left coronary artery and the right coronary artery branch off from the left posterior and anterior aortic sinuses, respectively.
Encircling the heart, the coronary arteries form a ring-like structure before...
Encircling the heart, the coronary arteries form a ring-like structure before...
1.6K
Aneurysm I: Introduction
366
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
366


