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将IgE介导的CMPA与功能性胃肠道疾病联系起来.
Nur Kevser Özyurt1, Merve Kişioğlu2, Burcu Güven3
1Department of Pediatrics, Faculty of Medicine, Karadeniz Technical University, Üniversite Mahallesi, Farabi Cd. No:64, 61080, Trabzon, Turkey.
European journal of pediatrics
|October 14, 2025
概括
婴儿牛奶蛋白过敏 (CMPA) 并没有增加长期功能性胃肠道疾病 (FGID) 的风险. 然而,IgE介导的CMPA与功能性消化不良,功能性腹痛和刺激性肠综合征的更高率有关.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 牛奶蛋白过敏 (CMPA) 被认为是儿科功能性胃肠道疾病 (FGID) 的潜在因素.
- 现有文献表明,CMPA可能会使儿童易患FGID或与FGID共存.
研究的目的:
- 确定婴儿CMPA诊断是否是FGID的长期风险因素.
- 为了比较IgE介导和非IgE介导的CMPA之间的FGID发展.
- 根据CMPA类型调查FGID流行率的差异.
主要方法:
- 一项涉及500名年龄在4-18岁的儿童的病例控制研究.
- 250名参与者有婴儿CMPA诊断史,250名年龄匹配的对照组没有CMPA.
- 父母填写了基于罗马四号标准的调查问卷,以评估FGID.
主要成果:
- 在CMPA患者 (28%) 和对照组 (30.4%) 之间,FGID的总体发生频率相似.
- 在没有CMPA的儿童中,功能性腹痛 - 其他未指明 (FAP-NOS),刺激性肠综合征 (IBS) 和非保留性便失禁 (NRFI) 较为普遍.
- 功能性消化不良 (FD),FAP-NOS和IBS在IgE介导的CMPA患者中比非IgE介导的CMPA患者更为常见.
结论:
- 长期的FGID发展在有CMPA史的儿童中没有升高.
- IgE介导的CMPA与FD,FAP-NOS和IBS的发病率增加有关.
- 亚临床CMPA可能会在IgE介导的CMPA患者中持续存在,导致FGID症状.
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