在星星和突触之间D-Serine的旅程
Sarah Mountadem1, Stéphane Henri Richard Oliet1, Aude Panatier2
1Univ. Bordeaux, INSERM, Neurocentre Magendie, U1215, F-33000, Bordeaux, France.
Neurochemical research
|October 14, 2025
概括
星球细胞释放D-氨酸,这是一个关键的质递质,它调节NMDA受体活性,突触可塑性和记忆力. 星球细胞中D-氨酸合成受损可能导致神经退行性疾病中的认知缺陷.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 突触性可塑性 突触性可塑性
背景情况:
- 星球细胞是调节突触传播的关键质细胞.
- D-氨酸是影响NMDA受体 (NMDAR) 功能的一种关键的 Gliotransmitter.
- 星系D-氨酸会影响认知过程和依赖NMDAR的功能.
研究的目的:
- 为了回顾天体细胞D-氨酸的多方面的作用.
- 要突出关于D-氨酸对NMDAR活性,突触可塑性和记忆的调节的发现.
- 讨论D-氨酸合成受损在神经退行性疾病中的影响.
主要方法:
- 审查现有的文献和实验室发现,跨越了二十年.
- 研究星细胞-神经元通信通路.
- 对D-氨酸在突触裂动态和认知功能中的作用的分析.
主要成果:
- 星细胞D-氨酸动态控制NMDAR活动和长期的突触可塑性.
- 天体细胞形态可塑性,细胞内Ca2+和特定受体 (CB1,EphB3) 影响D-氨酸的可用性.
- 缺陷的天体细胞D-氨酸合成会影响协同激素的可用性和认知功能.
结论:
- 星系细胞D-氨酸对于星系细胞与神经元的通信至关重要.
- D-氨酸在包括记忆在内的高阶大脑功能中起着重要作用.
- 天体细胞D-氨酸的失调与阿尔茨海默氏症等疾病的认知障碍有关.
更多相关视频
08:06Preparation of Synaptic Plasma Membrane and Postsynaptic Density Proteins Using a Discontinuous Sucrose Gradient
Published on: September 3, 2014
31.9K
08:27Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
Published on: March 11, 2020
6.5K
相关概念视频
Neurochemical Transmission: Sites of Drug Action
3.4K
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
3.4K
Overview of Synapses
4.6K
A synapse is a specialized structure where two neurons connect, allowing them to pass an electrical or chemical signal to another neuron. It is the point of communication between neurons. The term "synapse" is derived from the Greek word "synapsis," which means "conjunction." The entire process of neural communication revolves around the synapse. When activated, a neuron releases chemicals known as neurotransmitters into the synapse. These neurotransmitters cross the synapse and bind to...
4.6K
The Synapse
132.4K
Neurons communicate with one another by passing on their electrical signals to other neurons. A synapse is the location where two neurons meet to exchange signals. At the synapse, the neuron that sends the signal is called the presynaptic cell, while the neuron that receives the message is called the postsynaptic cell. Note that most neurons can be both presynaptic and postsynaptic, as they both transmit and receive information.
132.4K
Chemical Synapses
11.1K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
11.1K
Chemical Synapses
4.2K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
4.2K
Membrane Asymmetry Regulating Transporters
6.8K
Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
6.8K
