帕纳克斯人参C.A.发酵过程 与乳酸细菌一起的Meyer提取物通过激活NRF2通路来发挥肝保护作用
Jia-Jun Liang1,2, Hong-Xia Liu1, Jian-Gang Yan1
1Perfect (Guangdong) Co., Ltd, Zhongshan, 528451, China.
Journal of molecular histology
|October 14, 2025
概括
发酵Panax人参提取物 (FGE) 通过激活NRF2通路来保护肝脏. 这种机制涉及罕见的金色化物,减少氧化应激,改善肝功能在AAPH诱导的肝损伤.
科学领域:
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
- 自然产品 自然产品
背景情况:
- 发酵Panax人参C.A.精确的机制 迈耶提取物 (FGE) 在保护肝脏方面仍然不清楚.
- 氧化应激是肝损伤的一个关键因素.
研究的目的:
- 调查FGE的肝保护作用和潜在机制.
- 探索NRF2通路在FGE肝脏保护作用中的作用.
主要方法:
- 在体内和体外建立了AAPH诱导的肝损伤模型.
- 分析了病理损伤,肝功能障碍标志物和氧化应激指标 (SOD,GPx,ROS).
- 研究了NRF2通路组件 (KEAP1,HO-1,NQO1) 的表达和核转移.
主要成果:
- FGE显著改善了肝脏病理和功能.
- FGE增加了SOD和GPx表达,同时减少了活性氧物种 (ROS) 的产生.
- FGE调节了KEAP1,HO-1和NQO1的表达,并增强了NRF2蛋白表达和核转位.
结论:
- FGE对AAPH诱导的肝损伤表现出显著的肝保护作用.
- NRF2信号通路是FGE抗氧化和肝脏保护作用的关键调解者.
- 在FGE中罕见的雌激素可能有助于NRF2通路的激活.
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