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对性结肠炎和结肠癌的共享生物标志物LCN2和CXCL11:生物信息学分析和诊断模型构建

Zhihao Wu¹, Xiaofen Sun¹, Binglong Li¹

¹Department of Radiology, The First Clinical College, The First Affiliated Hospital, Hainan Medical University, Haikou, 570100, People's Republic of China.

Digestive diseases and sciences

|October 14, 2025

概括

性结肠炎和结肠癌具有共同的诊断标志物和炎症途径. 多基因诊断模型在这些疾病中显示出比单基因检测更高的准确性.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

慢性炎症,特别是性结肠炎,显著提高结肠癌的风险 (2-3x一般人口).
性结肠炎是一种复杂的慢性炎症状况.
了解性结肠炎和结肠癌之间的共同分子机制对于早期检测和治疗至关重要.

研究的目的:

为了确定性结肠炎和结肠癌之间的常见诊断标记.
调查共享的致病途径和免疫微环境的相似性.
开发和评估这些疾病的多基因诊断模型.

主要方法:

来自GEO和TCGA数据库的转录组数据分析.
使用权重基因同表达网络分析 (WGCNA) 和差异表达分析进行基因鉴定.
机器学习算法 (MCC,LASSO,RF) 和途径分析 (GO,KEGG,GSEA) 用于核心基因和途径识别.

主要成果:

在性结肠炎和结肠癌之间发现了87个常见的差异表达基因.
鉴定出LCN2和CXCL11是具有高表达和AUC>0.7.7的关键诊断基因.
途径分析揭示了免疫反应和细胞增殖的丰富,突出了共享的炎症机制.

结论:

性结肠炎和结肠癌具有共同的诊断标志物和病原性途径.
在免疫细胞透微环境中存在相似之处.
一个多基因诊断模型显示出比单基因更优越的诊断性能.

关键词:

生物信息学方法具有特征性的基因.大肠癌是什么意思大肠癌是什么意思诊断模型是一个诊断模型.免疫细胞透透.性结肠炎是一种

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