新型可的基于肺的补充剂降低了儿童的呼吸道感染:一项随机对照试验
Milos Jesenak1,2, Elena Prokopova3, Jan Bozensky4
1Department of Paediatrics and Adolescent Medicine, Jessenius Faculty of Medicine in Martin, University Hospital in Martin, Comenius University in Bratislava, Martin, Slovakia.
Advances in therapy
|October 14, 2025
概括
一种新型的可补充剂含有,维生素D和,有效地减少了患有复发性呼吸道感染 (RTIs) 的儿童的呼吸道感染 (RTIs). 这种干预措施显示出迅速开始采取行动,并为这个脆弱人群提供了有利的安全概况.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 复发性呼吸道感染 (RRTIs) 是儿童的重大健康问题,导致严重的社会经济负担.
- 贝塔-葡萄糖,就像Pleurotus ostreatus中的,通过病原体相关的分子模式受体相互作用具有免疫调节性质.
- 这项研究研究了一种新的可补充剂,它结合了,维生素D和,用于预防被诊断患有RRTIs的儿童的呼吸道感染.
研究的目的:
- 评估一种新型的基于肺的补充剂与维生素D和在预防患有复发性呼吸道感染 (RTIs) 的儿童的呼吸道感染 (RTIs) 的有效性.
- 评估二次终点,包括RTI亚型,持续时间,学校缺勤率和安全.
- 确定补充剂在患有RRTIs的儿科患者群体中的起作用和安全概况.
主要方法:
- 一项国际,多中心,随机,双盲,安慰剂对照试验与斯洛伐克,捷克共和国和塞尔维亚的249名被诊断患有RRTIs的儿童进行.
- 参与者在呼吸道感染季节 (10月至3月) 三个月内接受了基于的补充剂 (IMG®含维生素D和) 或活性安慰剂 (维生素D和).
- 主要终点是呼吸道感染 (RTIs) 的总数,次要终点关注RTI亚型,持续时间,错过的学校日和安全评估.
主要成果:
- 该研究包括217名儿童 (104名活体,113名安慰剂) 完成了试验. 活性补充剂组与安慰剂组相比,在统计学上显著地减少了整体RTIs (在3个月内减少15.2%,P=0.042).
- 观察到普通感冒发作 (18.6%;P=0.040) 的显著减少,特别是在6岁以上的儿童中. 喉炎的频率和持续时间也显著下降 (分别P=0.003和P=0.009).
- 该补充剂表现出快速起作用,在第一个月后效果明显. 它被很好地容忍,98.7%的遵守率,只有轻微的不良事件报告.
结论:
- 含有维生素D和的可腹膜补充剂显著降低了RRTIs儿童呼吸道感染的发生率.
- 该干预措施表现出迅速开始的治疗效果和良好的安全性,表明其作为预防措施的潜力.
- 这种补充剂代表了一种有希望的治疗选择,用于管理和预防患有RRTIs的脆弱儿科患者的呼吸道感染.
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