相关实验视频

Updated: Jan 6, 2026

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

最佳的图像衍生输入函数模型用于多参数分析,并可接受地减少了在[¹⁸F]F-FAPI-42 PET全身动态成像中用于肺癌的获得时间

Jiahao Xie¹, Dazhi Shi¹, Ganghua Tang¹

¹Department of Nuclear Medicine, Nanfang Hospital, Southern Medical University, Guangzhou North Road, Guangzhou, China.

|October 14, 2025

概括

右心室输入功能 (RVIF) 模型是肺癌中F-FAPI-42动态PET/CT的最佳选择,可在26分钟的扫描时间缩短后准确量化动力参数.

科学领域:

核医学就是核医学.
放射化学放射化学是指辐射化学.
在瘤学瘤学.

背景情况:

肺部瘤具有双重血液供应,可能会影响PET成像中的动力参数.
[¹⁸F]F-FAPI-42是一种用于成像纤维细胞激活蛋白 (FAP) 的新型标记物.
准确的动力参数量化对于评估瘤特征至关重要.

研究的目的:

评估影响[¹⁸F]F-FAPI-42在肺癌中的动力参数量化因素.
为了确定最佳的图像衍生输入函数 (IDIF) 模型.
为动态PET/CT扫描建立可接受的缩短采集时间.

主要方法:

19名肺癌患者接受了60分钟的动态F-FAPI-42 PET/CT.
动力参数 (K1-K3,Ki) 使用两种组织不可逆性比较 (2TiC) 模型进行计算.
评估的IDIF模型 (右心室[RV],左心室[LV],下垂大动脉[DA]),瘤大小,位置和亚型.

主要成果:

该RVIF模型的动力参数可与仅26分钟的60分钟扫描相提并论.
在RVIF和LVIF模型中,瘤大小显著影响了动力参数.
瘤位置和病理学亚型没有显著影响量化.
图像质量指标 (SUVmean,SNR,CNR,TBR) 在缩短获取时间时仍然很高.

结论:

在肺癌中,RVIF模型优于下降性大动脉输入功能 (DAIF) 模型的F-FAPI-42动力分析.
使用RVIF模型,缩短26分钟的采集时间是可行的和可靠的.
这种优化的协议可以提高肺癌PET/CT成像的效率.

关键词:

动脉输入功能的动脉输入功能.动态成像 - 动态成像短时间成像技术整体体质的PET/CT.[18F]F-FAPI-42 在F-FAPI-42 中

更多相关视频

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Management of Respiratory Motion Artefacts in 18F-fluorodeoxyglucose Positron Emission Tomography using an Amplitude-Based Optimal Respiratory Gating Algorithm

Published on: July 23, 2020

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

相关概念视频

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET