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涉及骨失调的新型filamin基因变异:综合结构建模和在的功能表征

Maha Yousaf1, Ayesha Zaka1, Shaheen Shahzad1

  • 1Genomics Research Lab, Department of Biological Sciences, International Islamic University Islamabad, Islamabad, Pakistan.

Journal of biomolecular structure & dynamics
|October 14, 2025
PubMed
概括

纤维素突变会导致骨功能障碍,如部部数字综合征-1和脊柱状关节结节综合征. 计算分析证实这些FLNA和FLNB变体破坏蛋白质结构和功能,导致骨生长异常.

关键词:
长丝纤维素 (filamins) 是一种材料.在的结构和功能研究.分子对接研究研究.分子动态模拟试验试验.骨发育不良症 骨发育不良症整体外基因组测序的测序

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