定义和管理慢性鼻炎的急性恶化
Keeler Kime1, Ahmad R Sedaghat, Katie M Phillips
1Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Current opinion in otolaryngology & head and neck surgery
|October 14, 2025
概括
了解慢性鼻炎 (CRS) 和其急性恶化 (AECRS) 的进展包括遗传风险因素和微生物群洞察力. 生物疗法看起来很有前途,但仍然需要一致的定义和管理策略.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 遗传学 是一个遗传学.
背景情况:
- 慢性鼻炎 (CRS) 和其急性恶化 (AECRS) 缺乏标准化的定义和管理策略.
- 目前的研究探讨了遗传倾向,微生物影响和炎症途径.
研究的目的:
- 审查关于CRS和AECRS的当前研究.
- 介绍诊断和管理策略的最新进展.
主要方法:
- 对遗传关联,微生物组研究和治疗干预的文献综述.
- 对生物疗法,抗生素治疗和成本效益模型的分析.
- 包括一个新提议的AECRS.患者知情定义.
主要成果:
- 一种CDHR3基因变异是AECRS的风险因素,与病毒复制和改变的免疫反应有关.
- 在AECRS患者体内常常存在形成生物膜的罕见微生物;微生物组分析至关重要.
- 针对2型炎症的生物疗法减少了恶化和皮质类固醇依赖.
- 培养导向抗生素可能提供长期内镜效益,但短期症状改善是不确定的.
- 观察通常是AECRS管理的最具成本效益的初始策略.
结论:
- 遗传学,微生物组研究和生物学为CRS和AECRS提供了新的治疗途径.
- 不一致的定义和结果指标阻碍了进步.
- 为了协调定义和标准化管理,进一步进行强有力的长期研究至关重要.
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