膀无毒素A 抗生素预防:一个潜在的RCT
Lauren Gleich1,2, Chen Shenhar2,3, Jacquelyn Booher2,4
1Department of Urology, Thomas Jefferson University Hospitals: Jefferson Health, Philadelphia, PA.
Urogynecology (Philadelphia, Pa.)
|October 14, 2025
概括
一次剂量的抗生素有效地预防尿路感染 (UTI) 后,膀上abotulinumtoxinA (BoNT-A) 注射过活的膀 (OAB). 这种方法与多次剂量一样安全,简化了这种常见程序的预防.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 膀上abotulinumtoxinA (BoNT-A) 是过度活跃的膀 (OAB) 的一个关键治疗方法.
- 术后尿路感染 (UTI) 是BoNT-A注射后最常见的不良事件.
- 目前的指导方针缺乏针对BoNT-A程序的具体抗生素预防建议.
研究的目的:
- 为了确定单一剂量临程抗生素是否与多剂量在预防BoNT-A后尿路感染方面不劣.
- 为了比较单个和多个抗生素剂量组之间的不良事件的发生率,包括尿液保留.
主要方法:
- 一个前性的,随机的,非盲目的,非劣等性试验,涉及96名接受办公室膀BoNT-A.A.的妇女.
- 患者被随机分配,接受单剂量抗生素或为期3天的抗生素疗程.
- 排除标准包括有复发性尿路感染或尿的病史. 患者在4周内被监测尿路感染,保留和其他不良事件.
主要成果:
- 在单剂量和多剂量抗生素组中,尿路感染的发病率为2% (P=0.95).
- 由于整体尿路感染率较低,没有达到非劣质性.
- 多剂量组中的一名患者经历了需要导管治疗的尿路保留,另一个患者患上了阴道酵母感染.
结论:
- 一次口服抗生素剂量似乎足以预防UTI在接受办公室膀BoNT-A治疗无并发性OAB的患者中.
- 这一发现简化了对该程序的抗生素预防建议.
- 需要进一步的研究来证实这些结果在更广泛的患者群体.
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