心血管系统生理学和病理学中的外源和内源抗氧化剂 (ROS)
Ghassan Bkaily1, Danielle Jacques2, Ashley Jazzar3
1Université de Sherbrooke, Dép. d'immunologie et de biologie cellulaire Faculté de médecine , Sherbrooke, Quebec, Canada; ghassan.bkaily@usherbrooke.ca.
Canadian journal of physiology and pharmacology
|October 14, 2025
概括
反应性氧物种 (ROS) 是由内源性抗氧化剂 (如谷氨和 taurine) 调节的,这对心血管健康至关重要. 虽然外源性抗氧化剂具有不确定的益处,但内源性抗氧化剂在预防心血管功能障碍方面表现有前途.
科学领域:
- 生物化学 生物化学
- 心血管科学 心血管科学
- 细胞生物学 细胞生物学
背景情况:
- 反应性氧物种 (ROS) 是细胞代谢的生理副产物,主要由线粒体和NADPH氧化酶产生.
- 细胞内ROS水平受到内源性抗氧化剂的严格调节,包括对心血管系统功能至关重要的谷氨 (GSH) 和牛素.
- 在食物中发现的外源抗氧化剂补充了内源系统,但它们对心血管的益处仍在争论中.
研究的目的:
- 在心血管健康的背景下,审查内源和外源抗氧化剂的优缺点.
- 探索特定内源性抗氧化剂在预防心血管疾病方面的潜在应用.
主要方法:
- 文献综述和综合现有关于ROS,抗氧化剂和心血管疾病的研究.
- 对内源性与外源性抗氧化系统的作用和有效性的比较分析.
- 讨论关于抗氧化剂对心血管功能的影响的科学证据.
主要成果:
- 内源性抗氧化剂,如谷氨和氨酸,在管理ROS和预防心血管功能障碍方面发挥着至关重要的作用.
- 外源抗氧化剂 (如维生素C,E,复星) 在预防心血管疾病方面的有益作用并未得到科学文献的一致支持.
- 内生抗氧化剂似乎为心血管系统提供了更可靠的保护.
结论:
- 与外部抗氧化剂相比,内源抗氧化剂在维持心血管健康方面发挥了更一致和更重要的作用.
- 对内源性抗氧化剂的具体机制和应用的进一步研究可能会产生新的心血管疾病预防策略.
- 氨酸和谷氨是关键的内源性抗氧化剂,在心血管医学中具有潜在的治疗应用.
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