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泰勒-库兹克风险模型:它对所有种族有效吗?
Siya Patil1, Nikki A Mehran1, Joel Erblich2
1Department of Diagnostic, Molecular and Interventional Radiology, Mount Sinai West, New York, NY, United States of America.
Clinical imaging
|October 14, 2025
概括
泰勒-库兹克8 (TC8) 模型预测乳腺癌风险,但其有效性因种族和族群而异. 这项研究突出了MRI查资格的潜在偏见,特别是在黑人和西班牙裔患者中.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 泰勒-库兹克8 (TC8) 风险模型对于估计乳腺癌风险和指导MRI查资格至关重要.
- 目前对TC8模型的评估还没有广泛评估其在不同种族和民族群体中的表现.
研究的目的:
- 评估TC8风险模型在多样化的美国城市人口中的预测准确度.
- 确定不同种族和族群之间乳腺癌风险评估和MRI查建议的潜在差异.
主要方法:
- 来自五个城市医疗保健站点的73,435名患者 (2018-2022) 的回顾性分析.
- 根据种族和种族分层计算TC8风险得分.
- 统计分析以评估TC8分数,癌症发病率和人口因素之间的关联.
主要成果:
- TC8得分与乳腺癌风险增加有显著的相关性 (OR=1.02每百分点增加).
- 白人患者的TC8得分最高,并且达到20%的MRI查门的几率最高.
- 黑人/AA和西班牙裔患者被诊断患有癌症的可能性较低,并且不太可能达到TC8值,这表明潜在的风险低估.
结论:
- 虽然TC8分数与不同组的癌症风险有关,但模型性能和值的实现存在差异.
- 目前20%的TC8门可能不适用于所有种族和族裔群体,可能导致少数群体的选不足.
- 在TC8模型中的潜在得分偏差可能会加剧乳腺癌护理中的种族差异,影响诊断,死亡率和发病率.
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