甲状腺功能低下症与辐射诱导的肺纤维化有关
Jinqiang You1, Lian Li2, Hongjuan Yang3
1Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin, China.
Breast (Edinburgh, Scotland)
|October 14, 2025
概括
甲状腺功能低下症显著增加辐射诱导肺纤维化 (RIPF) 的风险,乳腺癌患者接受放射治疗 (RT). 这一发现表明甲状腺功能可能是预防RIPF的可修改因素.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 内分泌学 在内分泌学.
背景情况:
- 辐射诱导性肺纤维化 (RIPF) 是乳腺癌放射治疗 (RT) 后的常见并发症.
- 乳腺癌患者经常出现甲状腺功能低下症,促使对其与RIPF的联系进行调查.
研究的目的:
- 在乳腺癌患者中研究甲状腺功能低下症和对辐射诱导肺纤维化 (RIPF) 的敏感性之间的关联.
主要方法:
- 对781名接受强度调节放射治疗 (IMRT) 的乳腺癌患者的回顾性分析.
- 使用单变量和多变量Cox回归和倾向分数匹配 (PSM) 来评估RIPF流行率和发生时间.
- 使用Kaplan-Meier生存分析来评估RIPF发生时间表.
主要成果:
- 甲状腺功能低下症在单变量和多变量分析中与RIPF敏感性有显著的关联 (ORs从5.51到5.85,P<0.001).
- 即使在倾向性得分匹配后,这种关联仍然显著 (单变 OR = 65.29,P = 0.02;多变 OR = 6.03,P < 0.001).
- 在PSM后的甲状腺功能低下症患者和没有甲状腺功能低下症患者之间,RIPF发生的中位时间相似 (6个月,P = 0.055).
结论:
- 甲状腺功能低下是接受术后IMRT的乳腺癌患者RIPF的重要危险因素.
- 甲状腺功能成为RIPF的潜在可修改风险因素.
- 对RIPF中甲状腺功能低下症的机制和干预措施的进一步研究是有必要的.
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