血清pepsinogen值在近距离乳牛中的重要性作为一个位移的腹膜预测标记:一个病例控制研究
Jun Nishinakagawa1, Shin Oikawa1, Kyoko Chisato1
1Department of Veterinary Medicine, School of Veterinary Medicine, Rakuno Gakuen University, 582 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.
Research in veterinary science
|October 14, 2025
概括
血清素 (PEP) 和非化脂肪酸 (NEFA) 可以预测牛的移位腹膜 (DA). 较低的PEP和较高的NEFA水平表明DA风险增加,PEP显示出更高的预测准确性.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 动物科学动物科学
- 生物化学 生物化学
背景情况:
- 移位腹部 (DA) 是乳牛常见的代谢障碍,严重影响群体健康和生产力.
- 早期发现和预测DA对于及时干预和改善治疗结果至关重要.
- 像pepsinogen (PEP) 和非化脂肪酸 (NEFA) 这样的血清生物标志物正在研究它们在预测DA的潜力.
研究的目的:
- 为了比较血清pepsinogen (PEP) 和胃素 (GA) 在牛的水平,发展移动腹膜 (DA) 与健康的对照.
- 评估血清PEP和NEFA度作为乳牛DA发展的预测指标的有用性.
- 评估PEP和NEFA对DA的联合预测能力.
主要方法:
- 在日本北海道的一个奶牛场进行了一项病例控制研究,涉及52例DA病例和108名健康对照.
- 血清PEP,胃素 (GA) 和NEFA度在牛产前和产后30天内测量.
- 还评估了身体状况得分 (BCS) 和乳头填充得分 (RFS);接收器操作特征 (ROC) 曲线用于预测分析.
主要成果:
- 与对照组相比,DA组的血清PEP和GA值明显较低.
- 具有PEP值≤700mU的奶牛的DA风险增加了10.9倍,而NEFA≥0.5mEq/L的奶牛的风险增加了2.8倍.
- 无论是PEP还是NEFA,都显示出DA的显著预测价值,而PEP更准确. 组合模型显示了最高的准确性.
结论:
- 血清PEP和NEFA度是乳牛中排离腹部的有价值预测指标.
- PEP是一个比NEFA单独更优秀的预测器.
- 结合PEP和NEFA可以提高DA预测的准确性,有助于早期诊断和管理策略.
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