评估放射治疗计划的稳定性:一个系统的文献审查
S Kim1, D Bernstein1, A Taylor1
1The Institute of Cancer Research, 123 Old Brompton Road, SW7 3RP, UK; The Royal Marsden NHS Foundation Trust, 203 Fulham Road, SW3 6JJ, UK.
概括
评估放射治疗治疗计划的稳定性至关重要,因为复杂的计划和缩小的利率. 目前的方法各不相同,缺乏共识,但为了提高安全性,建议结合基于剂量体积组图 (DVH) 和基于voxel的指标.
科学领域:
- 辐射疗法 辐射疗法
- 医学物理 医学物理
- 辐射瘤学 辐射瘤学
背景情况:
- 现代放射治疗采用符合规范和复杂的治疗计划.
- 降低的安全边际和低分化增加了对几何不确定性的脆弱性.
- 评估治疗计划的稳定性对于安全有效的放射治疗提供至关重要.
研究的目的:
- 为评估治疗计划稳健性提供当前实践的全面概述.
- 确定在稳定性评估中考虑的常见方法和不确定性.
- 强调在放射治疗计划评估中需要采用标准化的方法.
主要方法:
- 对评估计划稳定性的研究进行系统文献审查,截至2025年7月.
- 分析了225个符合纳入标准的出版物,从最初的287个开始.
- 强度评估方法的分类:基于剂量-体积组图 (DVH),基于voxel和放射生物学的指标.
主要成果:
- 质子疗法是大多数研究 (173/225) 的焦点.
- 最常被认为是设置和范围的不确定性.
- 方法各不相同,常见的是基于DVH的可视化,以及基于voxel和放射生物学的指标.
结论:
- 目前还没有国际共识来评估放射治疗计划的稳定性.
- 建议使用基于DVH和基于voxel的空间信息指标.
- 对于临床采用,需要标准化框架和集成软件工具.
相关概念视频
Cancer Survival Analysis
645
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
645
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
406
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
406
Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
Biological Effects of Radiation
17.6K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.6K


