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Updated: Jan 15, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

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HLA分子:对CAR T细胞治疗的另一个挑战

Ikram Salih1, Meryem Fakhkhari2, Hicham Berrougui3

  • 1Research Laboratory in Oral Biology and Biotechnology, Faculty of Dental Medicine, Mohammed V University in Rabat, Rabat, Morocco; Department of Medicine, Geriatric Service, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 4N4, Canada.

Current research in translational medicine
|October 14, 2025
PubMed
概括

卡特-T细胞疗法对血液癌症有前途,但面临着免疫逃避等挑战. 针对人类白细胞抗原 (HLA) 分子的策略,如HLA-G和HLA-DR,是提高CAR-T细胞有效性的关键.

关键词:
在CAR-T细胞疗法中.HLA分子中的HLA分子.在 HLA 调节方面.血液学的恶性瘤.免疫逃逸是一种免疫逃避.

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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL07:18

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