治疗型硬化症:当更少是更多的时候,更少是更多
Niamh Logan1, Jessica Raja1, Elisabetta A Renzoni2
1Department of Interstitial Lung Diseases, Royal Brompton Hospital, Dovehouse St, London SW36JY, UK.
Current opinion in immunology
|October 14, 2025
概括
Sarcoidosis 管理正在从长时间的高剂量类固醇转变为长期的高剂量类固醇.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 神经学 神经学
背景情况:
- Sarcoidosis 呈现异质,从自发缓解到神经病变和疲劳等致残症状.
- 危及器官或危及生命的类瘤需要修改疾病的疗法.
- 传统的葡萄糖皮质醇使用受到毒性担忧的挑战.
研究的目的:
- 审查当前的沙尔科毒症治疗策略.
- 为了突出转向减少类固醇使用的范式转变.
- 讨论替代性和基于症状的治疗方法.
主要方法:
- 关于当前的沙尔科毒症治疗的文献综述.
- 对最近的临床试验数据的分析.
- 专注于节制葡萄糖皮质激素的策略.
主要成果:
- 甲托雷克萨特在肺部型硬化症中显示出与葡萄糖皮质类药物相似的疗效,尽管效果延迟.
- 与葡萄糖皮质醇相关的毒性证据越来越多.
- "少就是多"的方法正在获得引力.
结论:
- 治疗策略正在不断发展,以尽量减少类固醇毒性.
- 基于症状的管理对于不响应的表现至关重要.
- 未来的肉增生症治疗强调量身定制的,少有毒的方法.
相关概念视频
COPD: Management Using Bronchodilators and Corticosteroids
726
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
726
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
434
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
434
Pericarditis III: Medical Management
307
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
307
Chronic Obstructive Pulmonary Disease-V: Management
3.1K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.1K
Pulmonary Tuberculosis V
534
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
534
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.5K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.5K


