结直肠癌青少年和年轻成年人的临床表现,管理和结果
Alyssa Stetson1, Shachi Srivatsa2, Lisa Tracy3
1Division of Pediatric Surgery, Department of Surgery, Mass General Brigham for Children, Mass General Brigham, Boston, Massachusetts.
The Journal of surgical research
|October 14, 2025
概括
大肠直肠癌 (CRC) 在青少年和年轻成年人 (AYA) 中很少见,但发病率正在上升. 这项研究分析了AYA CRC病例,揭示了各种表现和结果,强调需要改善儿科和成人提供者合作,以获得更好的护理.
科学领域:
- 在瘤学瘤学.
- 儿科瘤学 儿科瘤学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 在青少年和年轻人 (AYA) 中不常见,但其发病率正在增加.
- 与老年患者相比,被诊断患有CRC的AYA往往有较差的预后.
- 这项研究旨在描述AYA患者CRC的管理和结果.
研究的目的:
- 分析青少年和年轻人的结直肠癌的临床特征,治疗变异和结局.
- 确定影响这种特定患者群体预后的因素.
- 强调在AYA CRC管理中需要专业的护理和协作.
主要方法:
- 在四个机构对34名年龄在10-22岁的患者进行了回顾性分析,这些患者在2010年至2022年期间被诊断出结直肠腺癌.
- 排除患有癌性瘤的患者和在CRC诊断之前患有倾向综合征的患者.
- 数据收集包括患者人口统计,瘤阶段,淋巴结状况,接受的治疗和生存结果.
主要成果:
- 诊断时的中位数年龄为19岁,其中62%患有结肠癌,38%患有直肠癌.
- 在介绍时,74%的人患有≥T3阶段的疾病,29%患有转移性疾病.
- 随访时间中位数为2.2年,50%的人还活着,没有疾病的迹象,而26%的人已经去世.
结论:
- 青少年和年轻成人结直肠癌呈现出广泛的临床情景和结果.
- 由于AYA CRC的罕见性和越来越多的患病率,需要改善儿科和成人医疗保健提供者之间的合作.
- 通过跨学科合作优化护理可能会为患有结直肠癌的AYA患者带来更好的结果.
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